Zirconia microbead-helped ball processing and BASD are presently essentially utilized for the arrangement of single-digit dentonated nanodiamonds for examine, specifically, for adsorption and conveyance of insoluble hostile to growth therapeutics. The two systems needs the utilization of ?30 ?m ZrO2 microbeads. In BASD, for instance, the thick ZrO2 microbeads, pushed by the vitality of cavitation, impact and pulverize nanodiamonds totals caught in the middle of (figure 5). BASD yields the steady single-digit ND col-loids upto 10 wt% fixation with up to 80% yield in respect to the underlying ND mass. Be that as it may, BASD, and in addition ZrO2 microbead-helped ball processing have a few inconveniences, for example, a high cost (ZrO2 microbeads are costly, extraordinary plants must be intended for the procedure, detachment of microbeads from NDs is additionally expensive) and hard to evacuate ZrO2 garbage (unforgiving corrosive or base treatment is required to disintegrate ZrO2, which have contrarily impacts on creation security and adds to the cost of the filtered ND). Then again, if ZrO2 isn’t evacuated totally, at that point the nearness of this contaminant in uncontrolled amounts may contrarily impact the possibilities of clinical endorsement for ND empowered theranostic platforms73. In this way, ZrO2 and comparative artistic contaminants may represent a genuine snag while in transit to minimal effort and safe ND therapeutics. Despite what might be expected, water-dissolvable dry media-helped attritor processing and SAUD use modest, non-lethal, and non-polluting crystalline processing media, for example, sodium chloride or sucrose. Endless supply of the deg-gregation process, the processing media can be effortlessly washed out with water, giving an astounding preferred standpoint over a procedure containing insoluble earthenware globules. Notwithstanding, amid the dry media-helped attritor processing, parts of the factory defile nanodiamonds with Fe, Ni, and different segments of steel, so it required an additional purging advance. In addition, altogether lessening the total size from micrometer downsize to 50– 30 nm, dry media-helped attritor processing does not yield really single-digit nanodiamonds unless the scattering pH is acclimated to endless supply of milling83,84. SAUD utilizes ultrasonic power transport by a standard lab horn sonicator into suspensions of various water-solvent crystalline media (e.g., sodium chloride, potassium chloride, sodium acetic acid derivation, and so forth) to yield single-digit nanodiamonds colloids with no pH changes (figure 5). Since no ZrO2 is utilized, SAUD totally wipes out zirconia or some other hard to-evacuate debasements in nanodiamonds85. The mechanical activity of salt precious stones in SAUD is joined with development of a comparing salt of Na+, K+, and so forth with COO? gatherings of nanodiamonds, in this manner enhancing the steadiness of single-digit nanodiamonds colloid. In another approach, hydrogen tempering of nanodiamonds at 800 °C– 850 °C offers ascend to deaggregated hydrogen and – OH-ended nanodiamonds. These hydrogenated nanodiamonds demonstrate high colloidal strength in water because of their high positive zetapotential86,87.