Recentlyin the treatment of cancer with a chemotherapeutic approach DNA is the targetmolecule. Cisplatinand its derivatives are widely used as anticancer drugs but they create severalside effects such as anemia, diarrhea, alopecia, petechia, fatigue nephrotoxicity,emetogenesis, ototoxicity, and neurotoxicity .As a result, bioinorganic chemistsare focussing their attention on the design and synthesis of novel dynamicmetal complexes from bioactive ligands. Schiff bases are the class of ligands exhibitinginteresting coordination modes towards metal ions 1- 3.
Theazomethine linkage in Schiff base (-C=N-) is responsible for the biologicalactivities such as antibacterial,anti-proliferative, antimalarial, antifungal, anti-inflammatory, antiviral and antipyreticproperties. Antitumor, antibacterial, antifungal and herbicidalactivities 4. Schiff bases exhibit very important roles incoordination chemistry as they form stable complexes with transition metalions. Metal Schiff base complexes have been well known for their easysynthesis, stability and wide application5-7.
A large number ofSchiff base complexes have been reported so far, and their biological and catalyticactivity have been studied 8-14. O-Vanillin is also the mostprominent principal flavour and aroma compound in vanilla which is used as afood flavouring agent in foods, beverages and pharmaceuticals.6 Because of itsnumerous biological activities such as anti-inflammatory, analgesic, antiviralactivities, it is extensively studied in medicinal field.7-10 In addition, italso can be used as efficient herbicide, pesticide bactericides11 and Schiffbases containing o-vanillin moiety form stable complexes with various metal ions.12,13Hence, o-Vanillin is an optimal candidate for synthesizing various aromatic Schiffbases with significant bioactivities. In the present work, we discussed about the synthesis, dockingbiological activity, cytotoxicity, DNA binding and photo cleavage studies ofthe ligand and its metal complexes.
