Priyonath Adhikary, Sashikanta Sahoo, Pradeep Litoria, Brijendra Pateriya.Abstract:Water is the necessary element for life, but now day’s water pollution is the serious threat for all human being. Among the several type of water pollution, pollution by the arsenic is gained substantial attention in recent days. Arsenic is a naturally occurred element and it is widely distributed in earth crust. Drinking of arsenic contaminated water causes for serious health damage (chronic and carcinogenic). Therefore in present study was planned to assess contamination of arsenic and other mineral in drinking water of Jalandhar and Kapurthala Districts in Punjab, India.A total of 384 ground water sample was collected from different location of both districts, the half of sample was collected in pre-monsoon season and other data was collected in post-monsoon season from the same area. In this study we not only assess the amount of arsenic available in drinking water, also study the seasonal variation of the amount of arsenic. In this study it was found that only one to two percent of ground water was unfit for drinking purpose, because some area of Kapurthala district ware found high-concentration of arsenic in drinking water it cross the World Health Organization safe limit of arsenic (0.01ml/l) in drinking water. It was also found that the amount of arsenic in ground water also rise in post-monsoon season in pre-monsoon season only 1% of sample are cross the safe limit but in post monsoon season 5% of samples are cross the safe limit.Health risk assessment due to arsenic contaminated drinking water ware estimated by calculating Average daily dose, hazard quotient and cancer risk. It is found that like whole kapurthala district and south western and middle part of Jalandhar district has high HQ (<4) it indicate those area are at the serious health risk, and those area are more cancer porn area. This study highlights that urgent management and monitoring are taken place for the people in the study area, in order to minimize the water pollution and also provide hygienic water for drinking purpose. Keywords: Average daily dose, Health quotient (HQ), Cancer risk, World Health Organization.