Introduction random multi-center trail. Background One definition

Introduction Thisarticle examines the efficacy of muscle exercise in patients with muscledystrophy as well as a systematic review showcasing a missed opportunity toimprove outcomes. The main purpose of this study is to assess the role in whichexercise interventions on muscle strength in patients with muscle dystrophyplay. The methods used within this study were systematic electronic searches inthe medicine field, sources such as Embase, Web of Science and Pedro andreferenced literature were all utilized. Trials that assessed muscle exercisein the patients with muscle dystrophy were included and for the purpose ofdenouncing biasness two (2) reviewers independently abstracted data andappraised the study.

  Thetrails comprised of two hundred and forty two (242) patients with the extensionof two ongoing randomized controlled trials and three being randomized clinicaltrials. In addition, meta-analysis was also executed. There was an absence ofevidence for the difference in endurance and muscle strength, however they bothshowed affects favouring muscle exercise.

Tonote, in 1978 effects of muscle exercise were published and this was the firststudy. Benefits associated with muscular exercise have been continuously seenin reports, however this reason for this could be that of biases and could ofcame from only a small extent of the studies. Even though there is decades ofresearch doctors still cannot give much advice so patients are left without basicinformation.

Therefore, the strength of fatigue, muscle and functioninglimitations should be investigated using a random multi-center trail.  Background            One definition for muscle dystrophy saysthat it is a genetic disorder that gradually weakens the body’s muscles andlimits an individual’s functional capacity. The cause of this disorder is whenthere is missing or incorrect genetic information that prevents the body fromcreating the proteins needed to build and maintain healthy muscles. A fewdecades have gone by three to be exact and this amount of time has lead togreat progress within the field of muscular dystrophies. The most popular oneis the discovery of something that underline the disease, this being molecularand genetic causes. Unfortunately, there is no cure for muscle dystrophy andscientific advances has proven futile in discoveries of effective therapeutictools. As a result of this patients are left with essentially two optionscontinuous physiotherapy and symptomatic treatments.

            As it pertains to muscle tissuedisorders there has been sparks of debates about muscle exercise, if it isharmful or beneficial. These debates have made the role of exercise in dealingwith these patients controversial. When it comes to muscle loss in strength andtissue muscle exercise should prove to be valuable as it relates to offsettingthose losses because muscle weakness would be the key issue. However, evidenceshows that the effect of strength exercise in patients with muscular dystrophywould be seen as unreliable since it will be based more on personal accountsrather than facts. Therefore, it is important that systematic searches be doneto illustrate the effects of muscle exercise in experimental settings.

   Conclusion             Patients with muscular dystrophy usingmuscle exercise can have varied results, it could be either useful or uselessor even detrimental. The analysis done in this study does not dismiss any ofthose possibilities. The confidence intervals proved to be so wide that theycover all the possibilities (to advantages and disadvantages). This might havebeen because of the broad clinical heterogeneity between experimental designand clinical characteristics within the study or what little patients weregathered in the thirty years of research. In addition to this disease beingincurable, the question: “Is muscle exercise beneficial or detrimental inpatients that suffer from muscle dystrophy?” still went unanswered by theresearch community. Based on extensive research only five published trials wereretrieved, two of which are ongoing.

            The meta-analysis in this study wasinconclusive. Only five random controlled trials concentrated on the questionif muscle exercise can improve muscle strength in patients with muscledystrophy when compared to no intervention. Even though muscle exercise hasbeen proven to have a positive impact on other diseases, this finding cannot begeneralized to muscle dystrophy. As a result patients have to decide whetherthey want to start or continue muscle exercise based purely on expert opinionsor anecdotic experiences.

But, there is no proof on what type of exercise touse, the frequency and the intensity of the exercise. So, random controlledtrials targeting these aspects are urgently needed.             Some of the suggestions posed forthe next generation of random controlled trials were to focus on the strengthof muscle, fatigue and functional limitations.

As well as the implementation ofa new research governance strategy for neuromuscular disorders.References Gianola, S., Pecoraro, V., Lambiase, S., Gatti, R., Banfi,G., & Moja, L.

(2013). Efficacy of Muscle Exercise in Patients withMuscular Dystrophy: A Systematic Review Showing a Missed Opportunity to ImproveOutcomes. Plos ONE, 8(6), 1-9.



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