insufficiency and chronic pressure orsurgery. Even though antibacterial agents may control bacterial load andprevent the development of infection, they may also be toxic to fibroblasts andother viable cells. Compared to other antisepticagents, silver has a very weak toxic potential and rarely induces microbialresistance. Ancient Greeks and Romans used silver as a disinfectant. Many in vitro studies have demonstrated theeffectiveness of silver-based dressings against pathogenic bacteria. Hence, itis beneficial to use silver-releasing dressings in conjugation with debridementon wounds that are at a risk of developing infection.
Development of very smallsized silver particles that have large surface area and imparts greaterantimicrobial efficacy has been made possible with nanotechnology. Also, it lowerstheir toxicity to human tissue. AimThe study was conducted to compare the efficacy ofsilver colloidal dressings versus conventional dressings in management ofdiabetic foot ulcers.Methods· This single-centre randomised controlstudy was conducted on 37 patients with diabetic foot over a period of one yearwith Wagner Grade 1 and 2.· Patients with foot ulcer at least 2 cm2falling under Wagner grade I and II of at least 30 days duration, and fasting blood glucose level more than 126mg/dL or patients with known diabetes mellitus were included in the study.· Foot ulcer, which can be attributed toother coexisting disease like paraplegia, varicose, vein etc, patients sufferingfrom carcinoma, vasculitis, connective tissue disease, an immune systemdisorder, treatment with corticosteroids, immunosuppressive agents, radiation therapy,chemotherapy and patients with known hypersensitivity to colloidal silver gelwere excluded from the study.
· Patients were divided in to conventionaldressing group (n = 19) and silver colloidal dressing group (n = 18).· Conventional dressings group was managedwith debridement and povidone iodine/saline dressings, while silver colloidaldressing group was managed with debridement and application of silver colloidalgel dressing.· Patients were managed and followed upfor 12 weeks at two weeks interval.
Results· Almost all the patients enrolled in thestudy were diabetic for 6-15 years. Five patients in the silver group and sevenpatients in the conventional group were lost to follow up or opted out of thestudy.· At the end of 12 weeks only 13 and 12 patientswere left in each group. The mean age of silver group was 58.
23 ± 11.59(male-9, female-4) and in conventional group the mean age was 54.08±10.33 year(male-8, female-04).· Mean wound area in silver andconventional group on admission was 36.8 and 20.46 cm2 whichdecreased to 5.
28 and 6.42 cm2, respectively at 12 weeks (Table 1).The percentage decrease in wound area after 12weeks was more in silver group than conventional group (85.63% vs.