Inspired cell division is attributed to their free

Inspired by my father who is a professor in material sciences, I have alwaysbeen captivated by my surroundings and tried to understand them from differentaspects since young age.

This spark of curiosity has guided me through my chase ofseeking answers for my questioning mind, and resulted in my strong passiontowards research. It is the main motivation behind my pursuit of graduate studies.From second year of undergraduate study, I have dedicated myself to severalresearch projects, in domains of Mathematical Modeling, Super ResolutionMicroscopy, DNA Biophysics, Microfluidics, and Fluid Dynamics. These valuableexperiences deepened my understanding of these cutting edge topics in science andtechnology, and provided me chances to cultivate many experimental and analyticalskills. More importantly, I was inspired to decipher biological world withinterdisciplinary approach, which is well evidenced by the following researchexperience of mine.

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Professor Reyes-Lamothes has shown in his previous work that the evendistribution of bacterial high copy number plasmids at cell division is attributed totheir free diffusion, other than any molecular machinery that actively separatesthem. Inspired by this result, I proposed a project aiming to uncover thecontribution of physics in this process in an in vitro model, which is based onmicrofluidic platform. My knowledge in DNA polymer physics and microfluidicsystem enabled me to design the experiments and complete the project almostindependently.

My responsibilities included design and fabrication of themicrofluidic chips, surface characterization using SEM, DNA isolation, staining DNAwith intercalating fluorescent dyes, microscopy image acquisition, and data analysiswith a self-developed MATLAB algorithm. Throughout the project, I trained myselftoward an independent researcher who also functions equally well in a teamenvironment. Moreover, I demonstrated my ability to tackle obstacles and strongperseverance. It was also a good opportunity for me to enrich my laboratory skillsand knowledge in both biophysics and molecular biology.My hardworking has resulted in many awards, including Dean’smultidisciplinary research list, Leonard Katz Science Undergraduate ResearchAward and summer research fellowships, as well as being listed as second author inan article that has been submitted for peer review recently.

I was also selected topresent the above project at McGill Integrative Bioscience Student Society (MIBS)research symposium.In addition to my experience and skills in research, I have also preparedmyself for graduate study with a solid background in biology and mathematics. Ienrolled in courses, which would be of interest to me, challenge me, and aid me toprepare for my future as a scientist regardless of how difficult they were, includingBioinformatics, Biophysics, Imaging and Bio-instrumentation, Regression andAnalysis of Variance, Stochastic Processes, Molecular Biology, Nonlinear Dynamicsand a wide variety of courses in biology and quantitative subjects.

Holding high  standards for myself and never settling for less, I always strive to grasp a deeperunderstanding in each field than what is expected of me, even though my researchand courses covered a large range of topics. I welcome challenges with open armsbecause they remind me that I could achieve anything once I put my mind to it. Totest my potentials, I enrolled in Putnam Mathematics Competition Seminar, where Iencountered numerous new ideas and techniques, and enhanced my logical andcritical thinking.During my undergraduate study, I realized that my passion lies onintegrating engineering, mathematics, and physics to create and modify biologicalcomponent, such that it will meet people’s needs, and developing new techniquesthat advances biological study. I believe that this kind of research is highly neededand applicable to medical science, where the bridge between fundamental scienceand clinical application should be urgently built. With these thoughts, I aim topursue my graduate study in Biomedical Engineering, particularly in the fields ofsystems and synthetic biology, mechanobiology and biomaterials.Studying under the supervision of the following professors would make mygraduate study both challenging and enjoyable since their work closely representsmy research interests: Professor Rong Fan who develops single cell analysistechniques in order to debunk biological issues, such as cell signaling andheterogeneity, and advance clinical monitoring and diagnosis; Professor TarekFahmy who designs novel biomaterials that facilitate surgical therapy, drug deliveryand vaccine effectiveness; Professor Michael Murrell who probes the influence ofmechanical force on cell biology using various measurement techniques anddesigning artificial cell models; Professor Mark Saltzman who develops biomaterialsthat address medical issues, such as organ transplant, drug delivery, cancerdevelopment and etc.In addition to completing the Biomedical Engineering PhD program at Yale, Ialso intend to further develop a specialty in quantitative biology in the Physical andEngineering Biology (PEB) program.

This unique opportunity will further broadenmy vision of science by enrolling in interdisciplinary courses, engaging in extensivediscussion on cutting edge research, and working with faculties and students withvarious backgrounds.Yale University is my dream school for graduate study. Learning and workingin the world-class academic environment of the Biomedical Engineering departmentwill definitely make me mature fast as a scientist in my field and accomplish greatachievements in the exciting research.

The location of the university is anotherattraction to me. Situated in the emerging center of biotechnology and medical care,Yale certainly provides abundant opportunities and thriving environment forcollaboration and translational research.I intend to pursue an academic career in Biomedical Engineering afterreceiving my doctoral degree. As a researcher driven by curiosity, it is invigoratingfor me to lead a life of discovery while contributing to the society.

My ultimate goalis to improve the quality of life. Working as a researcher in Biomedical Engineeringallows me to contribute at all level, from participating in fundamental research toinventing solution of real-world problems. Last but not least, I enjoy teaching,another important aspect of academic career, very much. My experience as teaching assistant and co-founding an education company during my gap year (sinceSeptember, 2017) can bear testimony to this fact.

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