India, to BMI and cardiovascular risk factors like

India,often called the Diabetic Capital of the world stands first in the worldranking of countries with the highest number of diabetes patients. With over 70million diabetes cases, India has a serious necessity to focus more on thiskiller disease. Type 2 diabetes mellitus is a metabolic andendocrinological disease characterized by hyperglycemia associated with insulinresistance and/or defective insulin secretion 1. Cardiovascular disease has been reported to be the most important causefor sudden morbidity and mortality in diabetes patient. Ceruloplasmin(CP) is a copper-containing alpha-2-glycoprotein with a molecular weight ofapproximately 132 kDa. Ceruloplasmin has diverse functions 2.

The knownfunctions of ceruloplasmin include copper transportation, iron metabolism, antioxidantdefense, and involvement in angiogenesis and coagulation. It has been revealedthat ceruloplasmin catalyzes the oxidation of iron(II) to iron(III), and usesdioxygen as an electron acceptor without the mediation of an incompletelyreduced reactive oxygen species, such as a superoxide anion or hydrogenperoxide3. It has been established that serum ceruloplasmin level asa response to inflammatory process increases in subjects with cardiovascular disorders4.Reactive oxygen species disrupt copper binding to ceruloplasmin, therebyimpairing its normal protective function as liberated copper may generate freeradicals and oxidize LDL making it more atherogenic. Proinflammatory cytokines generated inadipose tissue can increase hepatic synthesis of Inflammation Sensitive Plasmaproteins like haptoglobin, fibrinogen, ?1-antitrypsin, and Cp. These wereused in clinical practice to measure the degree of inflammation and arerecognized as cardiovascular disease risk factors 5. Various studies had evaluated the associationbetween serum ceruloplasmin concentration and insulin resistance.

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Also studieshad evaluated the complexity of relation between serum ceruloplasmin andobesity.But only few studies have compared serum ceruloplasmin in relation to BMI and cardiovascularrisk factors like lipid profile in type 2 Diabetes mellitus patients. This study aims to predict the risk ofdeveloping cardiovascular diseases among type 2 diabetes patients having highBMI by correlating the serum ceruloplasmin levels with lipid profile. 

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