DRUG PROFILE 1. Bismuth Subcitrate Potassium Description: Bismuth

DRUG PROFILE1.      Bismuth Subcitrate PotassiumDescription: Bismuth subcitrate potassium is a mineral. Bismuth Subcitrate Potassium is a soluble, complex bismuth salt of citric acid used in combination with metronidazole and tetracycline to treat stomach ulcers caused by Helicobacter pylori infections. Structure: IUPAC Name: bismuth; pentapotassium;2-hydroxypropane-1,2,3-tricarboxylateMolecular formula: C12H10BiK5O14Molecular weight: 782.67 g/molMelting Point: 271.

3 °CpKa: 3.05Category: mineralDose: 140 mg Solubility: soluble in aqueous acids.  Storage: Store at -20°CIndications: Treatment of Helicobacter pylori infection and duodenal ulcer disease (active or history of within the past 5 years) to eradicate H. pylori Pharmacodynamics: Bismuth subcitrate is very effective in the treatment of gastroduodenal disorders and appears to act via several mechanisms. It has little acid-neutralizing effect and does not affect acid secretion. Mechanism of action:                         Colloidal bismuth subcitrate is very effective in the treatment of gastroduodenal disorders and appears to act via several mechanisms.

We Will Write a Custom Essay Specifically
For You For Only $13.90/page!


order now

It has little acid-neutralizing effect and does not affect acid secretion. It is uncertain whether it affects pepsin secretion, but it does inhibit peptic activity. It causes an increase in mucus glycoprotein secretion and may also bind to the gastric mucus layer to act as a diffusion barrier to HCl. It accelerates ulcer healing and causes an accumulation of epidermal growth factor around the ulcer. In addition, it has a cytoprotective effect and increases mucosal secretion of prostaglandins and bicarbonate.

It has bactericidal effects against Helicobacter pylori (which is associated with gastritis and peptic ulcers). It also prevents adhesion of H. pylori to epithelial cells and can inhibit enzymes secreted by H. pylori, such as proteases, lipases, glycosidases, and phospholipases.Absorption:                         The mean peak whole-blood bismuth level after ingestion of colloidal bismuth subcitrate (214 mg bismuth) was more than 50 mg/liter and occurred at 30 minutes. After ingestion of bismuth subnitrate (205 mg bismuth), however, there was no evidence of bismuth absorption into blood, although in three of the volunteers who took bismuth subnitrate a week after colloidal bismuth subcitrate, baseline levels of blood bismuth were still elevated.

Forty-five minutes after taking colloidal bismuth subcitrate, mean plasma levels for all five volunteers were also assessed and were 79.76 microg/liter as compared to blood levels of 47.6 microg/liter.Protein binding: more than 90%Route of elimination: Elimination of bismuth is primarily through urinary and biliary routes.Half-life: The elimination half-life of bismuth is approximately 5 daysAffected organism: Helicobactor pylori

x

Hi!
I'm Mary!

Would you like to get a custom essay? How about receiving a customized one?

Check it out