Cardiovascular diseases belong to a category of diseases in which detrimental effects occur on heart and blood vessels. Across the globe , these diseases are the most recurrent cause of human mortality. In India they are believed to account for about a quarter percent of demises. A notable disease affecting the heart is myocardial ischemia. In ischemia there is a deficiency in the amount of oxygen delivered due to limitation in blood flow. The reason behind constraint of blood flow in arteries is due to narrowing if arteries by plaque accumulation or obstruction due to clot appearance. The outcome is the injury to myocardial tissue in the state of Ischemic hypoxia. Various alterations are commenced in the cardiac tissue as a consequence of ischemia.
These involve morphological changes in terms of size of the cardiac tissue, enzymatic changes that pertain to the level and activity of myocardial associated enzymes.
Hemodynamic changes of decline in blood pressure, heart rate and ejection fraction
are also an aftermath of ischemia.
Arrhythmias may accompany cases of ischemia and some may be fatal.
The net result of these changes is the dysfunctioning of cardiac tissue contributing to heart complications such as heart attack , heart failure , etc
With the current lifestyle trend , incidence of ischemia and other ischemia related complications is on a rise.
Intensive research is being undertaken in hopes of finding cardioprotective agents that have significant reversal effects on ischemia.
Recently , the cardioprotective potential of oxytocin has been identified.
Oxytocin synthesized in hypothalamus and showing effects of uterine contraction during labor , milk ejection during lactation was also found to be synthesized in heart.
This possibility of cardiovascular role of oxytocin is implied by this.
The delivery of oxytocin to body effects the blood pressure, heart rate, etc..
Oxytocin enhances the production of Atrial natriuretic peptide which decreases the work load on heart by lowering the preload.
It also augments nitric oxide levels that decrease myocardial work load by increasing coronary circulation.
Hemodynamics changes were recorded in pregnant women administered with oxytocin and undergoing Caesarean section.
The present study tests the hypothesis that oxytocin exerts cardioprotective effects against ischemia.
To demonstrate the cardioprotective effect of oxytocin against ischemia in a dose dependent manner in an in vivo Rat by measuring the ejection fraction of left ventricle
To investigate the reversal effect of oxytocin on morphological changes of cardiac myocytes caused by ischemia in a dose dependent manner
To investigate the effect of oxytocin on the levels of biochemical markers of myocyte necrosis ( creatine- kinase MB isoenzyme amd lactate dehydrogenase )
To determine the cardioprotective effects of oxytocin with the scrutiny of injuries and infarct size.
To determine the electrophysiological effects of oxytocin on heart through the measurement of Heart rate by monitoring the R-R interval
To determine if oxytocin preconditioning has any therapeutic use by stabilizing blood pressure variations.