Cardiovascular diseases belong to a category of diseases in which detrimental effects occur on heart and blood vessels. Across the globe , these diseases are the most recurrent cause of human mortality.
In India they are believed to account for about a quarter percent of demises. A notable disease affecting the heart is myocardial ischemia. In ischemia there is a deficiency in the amount of oxygen delivered due to limitation in blood flow. The reason behind constraint of blood flow in arteries is due to narrowing if arteries by plaque accumulation or obstruction due to clot appearance.
The outcome is the injury to myocardial tissue in the state of Ischemic hypoxia. Various alterations are commenced in the cardiac tissue as a consequence of ischemia.These involve morphological changes in terms of size of the cardiac tissue, enzymatic changes that pertain to the level and activity of myocardial associated enzymes.Hemodynamic changes of decline in blood pressure, heart rate and ejection fraction are also an aftermath of ischemia.Arrhythmias may accompany cases of ischemia and some may be fatal.The net result of these changes is the dysfunctioning of cardiac tissue contributing to heart complications such as heart attack , heart failure , etcWith the current lifestyle trend , incidence of ischemia and other ischemia related complications is on a rise.
Intensive research is being undertaken in hopes of finding cardioprotective agents that have significant reversal effects on ischemia.Recently , the cardioprotective potential of oxytocin has been identified. Oxytocin synthesized in hypothalamus and showing effects of uterine contraction during labor , milk ejection during lactation was also found to be synthesized in heart.This possibility of cardiovascular role of oxytocin is implied by this.The delivery of oxytocin to body effects the blood pressure, heart rate, etc..Oxytocin enhances the production of Atrial natriuretic peptide and Nitric oxide which will decrease the work load on the heart by decreasing the preload and increasing the coronary circulation respectively.Hemodynamics changes were recordked in pregnant women administered with oxytocin and undergoing Caesarean section.The present study tests the hypothesis that oxytocin exerts cardioprotective effects against ischemia.