Animal rate and low incidence of spontaneous

            Animal models, such as mice andrats, are essential tools in scientific researches such as development ofmedical and veterinary discoveries.

People started using different animalmodels since the discovery of science itself. However, the usage of animals inresearch differs in different views of individuals. Even so, it is undeniablethat animal-based researches has been part of every medical discovery for morethan hundreds of years. Because of this, there is a rapid technological advancesand animal studies remains a need for scientific researches today and even infuture.            The most commonly used laboratoryanimal models are rats and mice. According to the Foundation for BiomedicalResearch (FBR), 95% of all laboratory animals are mice and rats. Researchers andscientists prefer rodents since they are small, easily housed and maintained,and can adapt well to new surroundings.

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They reproduce quickly and have a shortlife span of two to three years (Melina, 2010), which enablesresearchers to have several generations of offsprings within a reasonableperiod of time (Johnson, 2012). And also rodentsare relatively inexpensive compared to other animal models such as rabbits,cats, or dogs and it can be bought in large quantities from commercialproducers. Most mice and rats used in a clinical trial is of the same strain orbreed, for they are somewhat genetically identical, the only difference is thegenders.

Another reason is that according to a website article, humans and miceshare almost 95% of genes which made them an effective model for the human body(Undersatanding Animal Research, 2017) and is appropriatefor use to answer many research questions said Jenny Haliski, a representativefor the National Institute of Health (HIH) Office of the Laboratory AnimalWelfare. Majority of the commonly used mice in laboratories are albino. This isdue to a common mutation in tyrosinase gene. In which tyrosinase is one of thekey enzymes in mammalian melanin synthesis (Ramsden & Riley, 2014).

ICR strain,an albino, is a mouse model of Swiss origin and descended from the original twomale and seven female albino non-inbred mice (Research Models and Services, n.d.). This outbred strainwas named after the Institute of Cancer Research in the USA. The mice strain hasa docile nature, excellent reproductive and maternal instincts, rapid growthrate and low incidence of spontaneous tumor (Research Models and Services, n.d.).

ICR strain mice canbe used in almost all types of researches – oncology, immunology, toxicology,neurology, etc. 


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